Past Event: Oden Institute Seminar

Brain Tumors: Can Computational Modeling and Engineering Assist in Improving Clinical Outcomes?

Mateo Ziu, MD, Board-Certified Neurosurgeon and Assistant Professor of Department of Surgery/Perioperative Care, Dell Medical School at UT Austin

Abstract

There are approximately 120 histologically classified brain tumors. Some of these tumors are benign with better treatment options and outcomes, and there are some that by infiltrating eloquent areas of the brain make current treatment modalities challenging. Further, through continuous changes in their genetic apparatus, these tumors demand periodic changes in the treatment strategies with final result of escaping our control and ultimately causing patient demise. Recent advancements in molecular and genetic classification, imaging technology and new therapies have created an unprecedented opportunity to make an impact on patient survival and outcome. Brain is an organ where different cells work together to give rise to an interconnected functional network. It is paramount to consider these functional networks when discussing treatment options. Computational predictive analysis of tumor growth and surrounding functional network, machine learning and advance imaging integration of anatomy, molecular biology and genetics together with creation of decision-making and predictive algorithms hold the promise to advance our ability to improve patients outcome. I will guide you through the clinician journey in diagnosing and treating patients with brain tumors and together identify areas where computational predictive analysis and modeling can impact that journey. Bio Dr. Mateo Ziu is a Board-Certified Neurosurgeon and Assistant Professor of Department of Surgery/Perioperative Care at Dell Medical School at UT Austin. Dr. Ziu graduated from the University of Bari Medical School in Bari, Italy. He completed a research fellowship in neuro-oncology at the Neurosurgery Department, Harvard Medical School in Boston, MA. After completion of neurosurgery residency at UTHSCSA in San Antonio, he undertook a clinical fellowship in Neurosurgical Oncology at M.D. Anderson Cancer Center. His clinical interests are treatment of patients with brain, spine, pituitary and skull base tumors. He directs Brain and Spine Tumor Program of Seton Brain and Spine Institute in Austin, and serves as Co-Director of Neuro-Oncology and Pituitary Tumor Multidisciplinary Conferences at Network for Cancer Care. He collaborates as co-principal investigator in multiple clinical trials. Dr. Ziu has published multiple peer-reviewed articles relating to treatment and neurocognitive function of patients with brain and pituitary tumors.