Native-Ion Mobility-Mass Spectrometry and Structural Biology: Studies of Water and Water-Mediated Biomolecule Conformational Preferences
David Russell, Texas A&M University
2 – 3PM
Monday Sep 18, 2017
POB 4.304
Abstract
Ion mobility-mass spectrometry (IM-MS) provides size-based separations of gas-phase ions, and when coupled with “native”-electrospray ionization (N-ESI) it has enormous potential for structural characterization of biomolecules. The question is, do ions formed by ESI maintain their solution-like conformations upon transfer into the gas-phase? More importantly, for how long, under what conditions and to what extent are “native states” retained in the absence of solvent? This lecture will focus on a series of experimental and molecular dynamics simulation studies that are specifically designed to provide answers to these questions.